Article

CDC50 orthologues in <i>Plasmodium falciparum</i> have distinct roles in merozoite egress and trophozoite maturation

2022-01-20

Abstract excerpt

In model organisms P4-ATPases require cell division control protein 50 (CDC50) chaperones for their phospholipid flipping activity. In the malaria parasite, P. falciparum, guanylyl cyclase alpha (GCα) is an integral membrane protein that is essential for release (egress) of merozoites from their host erythrocytes. GCα is unusual in that it contains both a C-terminal cyclase domain and an N-terminal P4-ATPase doma...

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Literature Corpus work: 51aa2606-42f1-5f82-9a89-11edbac9bc76
DOI: 10.1101/2022.01.18.476868

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