Article

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

2020-09-30

Abstract excerpt

<h4>Synopsis</h4> <h4>Background</h4> SARS-CoV-2 is the causative agent of COVID-19 and a pathogen of immense global public health importance. Development of innovative direct-acting antiviral agents is sorely needed to address this virus. Peptide-conjugated morpholino oligomers (PPMO) are antisense agents composed of a phosphordiamidate morpholino oligomer covalently conjugated to a cell-penetrating peptide. PP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ba84af0-7195-5b37-b966-dd80ce6fcfac
DOI: 10.1101/2020.09.29.319731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomersDOI 10.1101/2020.09.29.319731Read

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers.Semantic proximity Read

Antisense oligonucleotide: A promising therapeutic option to beat COVID ‐19Semantic proximity Read

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replicationSemantic proximity Read

Inhibition of foot-and-mouth disease virus infections in cell cultures with antisense morpholino oligomers.Semantic proximity Read

A Promising Strategy Against SARS-CoV-2 Infected Patients: Antisense TherapySemantic proximity Read

A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of PicornavirusSemantic proximity Read

Antisense Oligonucleotide-Based Therapy of Viral InfectionsSemantic proximity Read

<strong>Think Different with RNA Therapy: Can Antisense Oligonucleotides Be Used to Inhibit Replication and Transcription of SARS-Cov-2?</strong>Semantic proximity Read

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimicsSemantic proximity Read

Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug DevelopmentSemantic proximity Read

Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral InhibitorsSemantic proximity Read

Unveiling the translational and therapeutic potential of small interfering RNA molecules in combating SARS-CoV-2: A reviewSemantic proximity Read