Article

The Pannexin-1 N-terminal Helix Gates a Switch between Ion Conductance and Anandamide Transport

2024-03-13

Abstract excerpt

Anandamide is an endovanilloid and endocannabinoid with ligand activity at transient receptor potential vanilloid 1 channels and cannabinoid receptors, respectively. We have reported that block of Pannexin-1 channels in the CA1 hippocampus can increase concentrations of anandamide and induce presynaptic plasticity. It is not known how an ion channel can contribute to clearance of a lipid-derived signalling molecul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 517fc1b4-e9a5-56d2-836c-55798b17acad
DOI: 10.1101/2024.03.11.584466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Pannexin-1 N-terminal Helix Gates a Switch between Ion Conductance and Anandamide TransportDOI 10.1101/2024.03.11.584466Read

TRPA1.Semantic proximity Read

Pannexins, a family of gap junction proteins expressed in brainSemantic proximity Read

Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.Semantic proximity Read

Structures of human pannexin 1 reveal ion pathways and mechanism of gating.Semantic proximity Read

Approaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy.Semantic proximity Read

Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits.Semantic proximity Read

Differential activation of mouse and human Panx1 channel variantsSemantic proximity Read

Neuronal Glutamate and GABAA Receptor Function in Health and DiseaseSemantic proximity Read

Epilepsy-associated Mutations in the Calcium-sensing Receptor Disrupt the Regulation of NALCN Sodium-leak Channel by Extracellular Calcium in NeuronsSemantic proximity Read

Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids.Semantic proximity Read

Mechanisms of anion conduction by coupled glutamate transporters.Semantic proximity Read

Position 552 in a FMRFamide-gated Na(+) channel affects the gating properties and the potency of FMRFamide.Semantic proximity Read