Article

Lysine metabolism conveys kidney protection in hypertension

2020-11-30

Abstract excerpt

<title>Abstract</title> <p>Hypertension and kidney disease, two related, common, and severe disease entities, have been repeatedly associated with genomic variants and metabolic alterations of lysine metabolism. Here, we developed a stable isotope labeling strategy compatible with untargeted metabolomics acquisition to investigate the physiology and molecular spectrum of lysine’s metabolic fate in vivo. Mice rece...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 515d623d-725f-596e-afe1-51b1415f73c3
DOI: 10.21203/rs.3.rs-108965/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysine metabolism conveys kidney protection in hypertensionDOI 10.21203/rs.3.rs-108965/v1Read

Sex-dependent metabolic remodeling of kidneys revealed by arteriovenous metabolomicsSemantic proximity Read

Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease.Semantic proximity Read

Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylationSemantic proximity Read

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and SignalingSemantic proximity Read

Metabolomic profiling of amino acids study reveals a distinct diagnostic model for Diabetic kidney diseaseSemantic proximity Read

Impaired renal gluconeogenesis is a major determinant of acute kidney injury associated mortalitySemantic proximity Read

A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression.Semantic proximity Read

Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.Semantic proximity Read

Serum Amino Acid Alterations in Hyperuricemia: Potential Targets for Renal Disease PreventionSemantic proximity Read

Tracing metabolic flux in vivo: basic model structures of tracer methodologySemantic proximity Read

Quantification of lactoyl-CoA by liquid chromatography mass spectrometry in mammalian cells and tissuesSemantic proximity Read

<i>In Vivo</i> Quantification of Histone Acetylation Turnover and Acetyl-CoA Sources Using ²H₂O Metabolic Labeling and High-Resolution Mass SpectrometrySemantic proximity Read