Article

Inhibition of Neuropilin-1 improves non-alcoholic fatty liver disease via PI3K/AKT/mTOR signaling in high-fat-diet induced obese mouse

2021-08-03

Abstract excerpt

<title>Abstract</title> <p>Background Research findings indicate Neuropilin-1 plays a critical role in lipid metabolism and obesity-associated insulin resistance, on such a basis, this study aims to explore the effects and working mechanism of Neuropilin-1 inhibition on the non-alcoholic fatty liver disease in high-fat-diet induced obese mice. Methods Firstly, the pcDNA3.1-NRP-1 recombinant plasmid containing N...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51569447-1352-54c9-862e-c3d7bb0bc6c7
DOI: 10.21203/rs.3.rs-665094/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Neuropilin-1 improves non-alcoholic fatty liver disease via PI3K/AKT/mTOR signaling in high-fat-diet induced obese mouseDOI 10.21203/rs.3.rs-665094/v2Read

Enpp1 ameliorates NAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathwaySemantic proximity Read

The Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease Through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq TranscriptomicsSemantic proximity Read

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins.Semantic proximity Read

Tirzepatide but not Semaglutide Ameliorates Hepatic Steatosis and Inflammatory Infiltration in a Mouse Model of MASLD via Inhibition of the CCL2/CCR2-PI3K-Akt PathwaySemantic proximity Read

VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathwaySemantic proximity Read

Neuropilins and liverSemantic proximity Read

The role of C5aR1-mediated hepatic macrophage efferocytosis in NASHSemantic proximity Read

LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitisSemantic proximity Read

Rap1 Activation Protects Against Fatty Liver and Non-Alcoholic Steatohepatitis DevelopmentSemantic proximity Read

Fat-1 Gene Inhibit Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in MiceSemantic proximity Read

Dynein Light Chain LC8 Alleviates Nonalcoholic Steatohepatitis By Regulating Nuclear Factor κB Through Interference With IκBα PhosphorylationSemantic proximity Read

Regulation and mechanism of mouse miR-130a/b in metabolism-related inflammation.Semantic proximity Read