The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH

Abstract excerpt

<title>Abstract</title> <p>NAFLD has become the first major chronic liver disease in developed countries. 10-20% of NAFLD patients will progress to NASH, and up to 25% of NASH patients may develop cirrhosis within 10 years. Therefore, it is critical to find key factors that may treat this disease. Here, we identified C5aR1 as a highly-expressed gene in NASH model mice through analyzing GEO database and confirmed...

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• Cancer-related molecular mechanisms research
• Cholesterol and Lipid Metabolism
• Diet, Metabolism, and Disease
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Liver Disease Diagnosis and Treatment
• MicroRNA in disease regulation
• Peroxisome Proliferator-Activated Receptors

Identifiers and source

Literature Corpus work

d316aad8-c468-533c-9771-0ba59b7d6ac6

DOI

10.21203/rs.3.rs-4166103/v1