Article

Male obesity causes adipose mitochondrial dysfunction in F <sub>1</sub> progeny via a let-7-DICER axis

2024-10-04

Abstract excerpt

We here describe that obesity and weight loss in male mice cause reversible abnormalities in glucose and lipid metabolism, serum metabolomes and lipidomes as well as expression of microRNAs, mRNAs and proteins controlling mitochondrial function in epididymal white adipose tissue. When mating obese male mice with lean females, we observed reductions in expression and translation of genes encoding mitochondrial resp...

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Identifiers and source

Literature Corpus work: 5155aa35-3fec-5ca3-adea-97328abd72ae
DOI: 10.1101/2024.10.03.615866

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