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Microfluidic Replication and Phenotypic Profiling of Extracellular Vesicles from the Tumor Microenvironment Using Dual-Switch Aptamer Logic Gates.

Analytical chemistry - 11 Mar 2025

Wu Qiaoyi, Wu Qiuyue, Lin Haoting, Zhang Chi, You Zhenlong, Kang Siyin, Xu Yuanfeng, Chen Xiaofeng, Yang Chaoyong, Song Yanling, Zhu Lin

Abstract excerpt

The phenotypic profiling of extracellular vesicles (EVs) within the tumor microenvironment (TME) provides critical insights into the intercellular communication mechanisms of EVs underlying tumor physiology. However, conventional methods typically isolate EVs from the extracellular space through tissue fragmentation, which compromises tissue viability, and neglects the spatial organization of the tissue and the...

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PMID: 40012368
DOI: 10.1021/acs.analchem.5c00234

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