Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

"Sample-to-Answer" Detection of Rare ctDNA Mutation from 2 mL Plasma with a Fully Integrated DNA Extraction and Digital Droplet PCR Microdevice for Liquid Biopsy.

Analytical chemistry - 19 May 2020

Geng Zhi, Li Shanglin, Zhu Lingxiang, Cheng Zhen, Jin Min, Liu Baoxia, Guo Yong, Liu Peng

Abstract excerpt

The "sample-to-answer" integration and automation of circulating tumor DNA (ctDNA)-based liquid biopsy using digital PCR (dPCR) has been hampered by the complicated operations of liquids with volumes ranging from milliliter samples to nanoliter droplets. On the basis of a "3D extensible" design paradigm proposed previously, an integrated droplet digital PCR (IddPCR) microdevice was successfully developed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circulating Tumor DNA
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 32323972
DOI: 10.1021/acs.analchem.0c00818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

"Sample-to-Answer" Detection of Rare ctDNA Mutation from 2 mL Plasma with a Fully Integrated DNA Extraction and Digital Droplet PCR Microdevice for Liquid Biopsy.PMID 32323972Read ↗

Current and Emerging Applications of Droplet Digital PCR in Oncology: An Updated Review.Semantic proximity Read ↗

Single-Cell Digital Microfluidic Mass Spectrometry Platform for Efficient and Multiplex Genotyping of Circulating Tumor Cells.Semantic proximity Read ↗

All-In-One OsciDrop Digital PCR System for Automated and Highly Multiplexed Molecular Diagnostics.Semantic proximity Read ↗

Liquid biopsy: current technology and clinical applicationsSemantic proximity Read ↗

Droplet-based digital PCR and next generation sequencing for monitoring circulating tumor DNA: a cancer diagnostic perspective.Semantic proximity Read ↗

A droplet digital LAMP-based lab-on-a-disc system for multiplex allele-specific detection of tumor-derived DNA mutations.Semantic proximity Read ↗

Improvement of the sensitivity of circulating tumor DNA-based liquid biopsy: current approaches and future perspectivesSemantic proximity Read ↗

Ultra-fast sample-to-sequencing workflow for clinical diagnostics using micropillarsSemantic proximity Read ↗

High-throughput single-EV liquid biopsy: Rapid, simultaneous, and multiplexed detection of nucleic acids, proteins, and their combinationsSemantic proximity Read ↗

Detection of EGFR gene with a droplet digital PCR chip integrating a double-layer glass reservoir.Semantic proximity Read ↗

A highly integrated digital PCR system with on-chip heating for accurate DNA quantitative analysis.Semantic proximity Read ↗

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis productSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.