Article

Structural and functional impact of non- synonymous SNPs in the CST complex subunit TEN1: Structural genomics approach

2018-12-27

Abstract excerpt

TEN1 protein is a key component of CST complex, implicated in maintaining the telomere homeostasis, and provide stability to the eukaryotic genome. Mutations in TEN1 gene have higher chances of deleterious impact; thus, interpreting the number of mutations and their consequential impact on the structure, stability and function is essentially important. Here, we have investigated the structural and functional conse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41505e06-8c7a-54ff-a421-a3b8046b6440
DOI: 10.1101/507046

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural and functional impact of non- synonymous SNPs in the CST complex subunit TEN1: Structural genomics approachDOI 10.1101/507046Read

Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1.Semantic proximity Read

Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus SyndromeSemantic proximity Read

A comprehensive in silico investigation into the pathogenic SNPs in the RTEL1 gene and their biological consequences.Semantic proximity Read

Computational Analysis of Single Nucleotide polymorphisms (SNPs) in Human TCell Acute Lymphocytic Leukemia Protein 1 (TAL1) Gene/Comprehensive StudySemantic proximity Read

Structural and functional analysis of disease-associated mutations in GOT1 gene: An in silico study.Semantic proximity Read

In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.Semantic proximity Read

The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.Semantic proximity Read

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics‐based approach to understand the mechanism of cancer developmentSemantic proximity Read

Mutation analysis of pathogenic non-synonymous single nucleotide polymorphisms (nsSNPs) in WFS1 gene through computational approaches.Semantic proximity Read

In-silico identification of deleterious non-synonymous SNPs of TBX1 gene: Functional and structural impact towards 22q11.2DS.Semantic proximity Read

Proteostasis Associated Mutations in HSPB5 Destabilize the αB-crystallin DomainSemantic proximity Read

Approaches and resources for prediction of the effects of non-synonymous single nucleotide polymorphism on protein function and interactions.Semantic proximity Read