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Structural and functional studies of D109A human αB-crystallin contributing to the development of cataract and cardiomyopathy diseases

29 Nov 2021

Abstract excerpt

αB-crystallin (heat shock protein β5/HSPB5) is a member of the family of small heat shock proteins that is expressed in various organs of the human body including eye lenses and muscles. Therefore, mutations in the gene of this protein (CRYAB) might have many pathological consequences. A new mutation has recently been discovered in the α-crystallin domain of this chaperone protein which replaces aspartate 109...

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PMID: 34843556
DOI: 10.1371/journal.pone.0260306

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Structural and functional studies of D109A human αB-crystallin contributing to the development of cataract and cardiomyopathy diseasesPMID 34843556Read ↗

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