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Article

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2020

Zhong Xiaolin, Huang Menghao, Kim Hyeong-Geug, Zhang Yang, Chowdhury Kushan, Cai Wenjie, Saxena Romil, Schwabe Robert F, Liangpunsakul Suthat, Dong X Charlie

Abstract excerpt

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood. Sirtuin 6 (Sirt6), a nicotinamide adenine dinucleotide-dependent deacetylase, has been implicated in fatty liver disease; however, the underlying molecular mechanisms in the...

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Identifiers

PMID: 32305562
DOI: 10.1016/j.jcmgh.2020.04.005
PMCID: PMC7327931

Genes

SIRT6
SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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