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OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming

15 Sept 2020

Abstract excerpt

OVOL proteins (OVOL1 and OVOL2), vertebrate homologs of Drosophila OVO, are critical regulators of epithelial lineage determination and differentiation during embryonic development in tissues such as kidney, skin, mammary epithelia, and testis. OVOL can inhibit epithelial-mesenchymal transition and/or can promote mesenchymal-epithelial transition. Moreover, they can regulate the stemness of cancer cells, thus...

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PMID: 32932250
DOI: 10.1159/000511383

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