Article

BRD2 impedes iPSC reprogramming by regulating lipogenesis and matrisome

2025-12-05

Abstract excerpt

<title>Abstract</title> <p>Induction of human pluripotent stem cells (HiPSCs) from somatic cells encounters significant barriers, which remain poorly understood. Lipids are fundamental cellular molecules with many essential roles. However, lipid roles in reprogramming are unknown. Here, we prove that BRD2 is a barrier to HiPSC reprogramming by suppressing lipogenesis and maintaining the somatic transcriptional pr...

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Literature Corpus work: 5ddc32b7-40b9-5b35-8d74-7892c24e5ecc
DOI: 10.21203/rs.3.rs-7744310/v1

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