Article

Conventional NK cells and ILC1 are partially ablated in the livers of Ncr1iCreTbx21fl/fl mice

2017-07-05

Abstract excerpt

Mouse liver contains both Eomes-dependent conventional natural killer (cNK) cells and Tbet-dependent liver-resident type I innate lymphoid cells (ILC1). In order to better understand the role of ILC1, we attempted to generate mice that would lack liver ILC1, while retaining cNK, by conditional deletion of Tbet in NKp46+ cells. Here we report that the Ncr1 iCre Tbx21 fl/fl mouse has a roughly equivalent reduction...

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Literature Corpus work: 504edc15-bb96-59eb-a250-e5ad77e02987
DOI: 10.12688/wellcomeopenres.11741.2

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