Article
Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2016
Verrier Thomas, Satoh-Takayama Naoko, Serafini Nicolas, Marie Solenne, Di Santo James P, Vosshenrich Christian A J
Abstract excerpt
Group 3 innate lymphoid cells (ILC3) actively participate in mucosal defense and homeostasis through prompt secretion of IL-17A, IL-22, and IFN-γ. Reports identify two ILC3 lineages: a CCR6(+)T-bet(-) subset that appears early in embryonic development and promotes lymphoid organogenesis and a CCR6(-)T-bet(+) subset that emerges after microbial colonization and harbors NKp46(+) ILC3. We demonstrate that NKp46...
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