Article

Long-term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus

2020-05-26

Abstract excerpt

Antigen 85B (Ag85B) is one of the most dominant proteins secreted from most mycobacterial species, and it induces Th1-type immune responses as an adjuvant. We genetically constructed a live attenuated simian human immunodeficiency virus to express the adjuvant molecule Ag85B (SHIV-Ag85B). SHIV-Ag85B could not be detected 4 weeks after injection in cynomolgus macaques, and strong SHIV-specific T cell responses were...

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Identifiers and source

Literature Corpus work: 503efc42-c3e4-52fc-924a-d6cbb2bc2ffd
DOI: 10.1101/2020.05.22.111781

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