Article
Novel simian immunodeficiency virus CTL epitopes restricted by MHC class I molecule Mamu-B*01 are highly conserved for long term in DNA/MVA-vaccinated, SHIV-challenged rhesus macaques.
International immunology - 1 May 2005
Su Jin, Luscher Mark A, Xiong Yelin, Rustam Tarick, Amara Rama Rao, Rakasz Eva, Robinson Harriet L, MacDonald Kelly S
Abstract excerpt
Simian immunodeficiency virus (SIV) infection of rhesus macaques provides an excellent model for investigating the basis of protective immunity against human immunodeficiency virus (HIV). One limitation of this model, however, has been the availability of a small number of known MHC class I-restricted CTL epitopes for investigating virus-specific immune responses. We assessed CTL responses against SIV Gag in a...
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