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Article

Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge

1 Oct 1999

Abstract excerpt

We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239Delta3, which is missing nef and vpr genes, to protect against challenge by heterologous strains SHIV89.6p and SIVsmE660. SHIV89.6p is a pathogenic, recombinant SIV in which the envelope gene has been replaced by a human immunodeficiency virus type 1 envelope gene; other structural genes of SHIV89.6p are...

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PMID: 10482586
DOI: 10.1128/jvi.73.10.8356-8363.1999

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