OTUB1/ NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death

Abstract excerpt

<title>Abstract</title> <p>Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis.Our previous study reveals that NDUFS2 (NADH: ubiquinone oxidoreductase core subunit S2), a core subunit of the mitochondrial respiratory chain complex I, is unregulated in Pancreatic adenocarcinoma (PAAD). However, its...

Topics

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• Autophagy in Disease and Therapy
• Cancer-related molecular mechanisms research
• Endoplasmic Reticulum Stress and Disease
• Ferroptosis and cancer prognosis
• Pancreatic and Hepatic Oncology Research
• Peptidase Inhibition and Analysis
• RNA modifications and cancer
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

9410636d-ca7f-53e6-bac8-5c66b278c8ed

DOI

10.21203/rs.3.rs-3421483/v1