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Article

Inhibition of the PI3K-Akt Pathway Suppresses sFlt1 Expression in Human Placental Hypoxia Models In Vitro

22 May 2010

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Share to Angiogenesis and VEGF in Cancer
Share to Cancer, Hypoxia, and Metabolism
Share to Pregnancy and preeclampsia studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20488538
DOI: 10.1016/j.placenta.2010.04.009

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Related research

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Inhibition of the PI3K-Akt Pathway Suppresses sFlt1 Expression in Human Placental Hypoxia Models In VitroPMID 20488538Read ↗

HIF-1α-mediated inhibition of the sFlt-1/sENG/TNF-α pathway promotes angiogenesis to ameliorate pre-eclampsiaSemantic proximity Read ↗

Placental‐Specific Overexpression of sFlt‐1 Alters Trophoblast Differentiation and Nutrient Transporter Expression in an IUGR Mouse ModelSemantic proximity Read ↗

Lin28 Enhances Glucose Metabolism in Human Placental Mesenchymal Stem Cells during Hypoxia via the PI3K-Akt PathwaySemantic proximity Read ↗

MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsiaSemantic proximity Read ↗

Human Placental Hypoxia-Inducible Factor-1α Expression Correlates with Clinical Outcomes in Chronic Hypoxia in VivoSemantic proximity Read ↗

RNAi modulation of placental sFLT1 for the treatment of preeclampsiaSemantic proximity Read ↗

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse ModelSemantic proximity Read ↗

Hypoxia activates the IGF-1 expression through STAT5b in human HepG2 cellsSemantic proximity Read ↗

Novel Splice Variants of sFlt1 are Upregulated in PreeclampsiaSemantic proximity Read ↗

Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic MiceSemantic proximity Read ↗

The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxiaSemantic proximity Read ↗

Genome-Wide Analysis of Hypoxia-Inducible Factor Binding Reveals Targets Implicated in Impaired Human Placental Syncytiotrophoblast Formation under Low OxygenSemantic proximity Read ↗

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