Article

Enhanced PRL-1 expression in placenta-derived mesenchymal stem cells accelerates hepatic function via mitochondrial dynamics in a cirrhotic rat model

2020-09-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Placenta-derived mesenchymal stem cells (PD-MSCs) have been highlighted as an alternative cell therapy agent that has become a next-generation stem cell treatment. Phosphatase of regenerating liver-1 (PRL-1), an immediate early gene, plays a critical role during liver regeneration. Here, we generated enhanced PRL-1 in PD-MSCs (PD-MSCs<sup>PRL-1</sup>, PRL-1+) us...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b865c68-4a12-52aa-981c-52ead1db9ecc
DOI: 10.21203/rs.3.rs-22313/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhanced PRL-1 expression in placenta-derived mesenchymal stem cells accelerates hepatic function via mitochondrial dynamics in a cirrhotic rat modelDOI 10.21203/rs.3.rs-22313/v3Read

Exosomes from Placenta-Derived Mesenchymal Stem Cells Are Involved in Liver Regeneration in Hepatic Failure Induced by Bile Duct LigationSemantic proximity Read

Activation of the EGFR-PI3K-CaM Pathway by PRL-1 Ameliorates Liver Cirrhosis via ER Stress-dependent CalciumSemantic proximity Read

Increased Phosphatase Regenerating Liver -1 Trigger Vascular Remodeling in Injured Ovary Via Platelet-derived Growth Factor Signaling PathwaySemantic proximity Read

A fat option for the pig: hepatocytic differentiated mesenchymal stem cells for translational research.Semantic proximity Read

Isolation and Characterization of AFP+/DLK1+ Double-Positive Hepatic Stem/Progenitor Cells from Fibrotic PHx ModelSemantic proximity Read

The multiple functional roles of mesenchymal stem cells in participating in treating liver diseasesSemantic proximity Read

Induction of hepatocyte‐like cells from human umbilical cord‐derived mesenchymal stem cells by defined microRNAsSemantic proximity Read

Mesenchymal stem cells derived exosomes ameliorate D-galN/LPS induced acute liver injury via PTEN-mediated macrophage polarizationSemantic proximity Read

Human embryonic stem cell-derived mesenchymal stem cells have potential of high differentiation into hepatocyte-like cells through increased level of hepatocyte growth factorSemantic proximity Read

Lin28 Enhances Glucose Metabolism in Human Placental Mesenchymal Stem Cells during Hypoxia via the PI3K-Akt PathwaySemantic proximity Read

Exosomal circ-RBM23 sponging miR-139-5p to promote liver regeneration through RRM2/AKT/mTOR pathwaySemantic proximity Read

Induction of differentiation and metabolic reprogramming in human hepatoma cells by adult human serumSemantic proximity Read