Article

Attenuated estrogen signaling disrupts placentation and drives trophoblast defects in Down syndrome

2026-06-08

Abstract excerpt

<h4>Summary</h4> Proper establishment of the primitive placenta and subsequent tissue homeostasis in the mature placenta are critical for successful pregnancy in humans. Placental insufficiency is associated with adverse pregnancy outcomes, including fetal growth restriction, preeclampsia, and pregnancy loss. Moreover, emerging evidence suggests that placental defects are associated with long-term health challeng...

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Literature Corpus work: fd0056d4-c58c-5269-86b7-de90af437216
DOI: 10.64898/2026.06.03.729739

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