Article

A Trisomy 21 Lung Cell Atlas

2023-04-03

Abstract excerpt

Trisomy 21 (T21), resulting in Down Syndrome (DS), is the most prevalent chromosomal abnormality worldwide. While pulmonary disease is a major cause of morbidity and mortality in DS, the ontogeny of pulmonary complications remains poorly understood. We recently demonstrated that T21 lung anomalies, including airway branching and vascular lymphatic abnormalities, are initiated in utero. Here, we aimed to describe m...

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Literature Corpus work: d85a624f-2528-5bb8-97e7-9b43b0ff4104
DOI: 10.1101/2023.03.30.534839

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