Article

Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19

2022-03-27

Abstract excerpt

Post-acute lung sequelae of COVID-19 are challenging many survivors across the world, yet the mechanisms behind are poorly understood. Our results delineate an inflammatory cascade of events occurring along disease progression within fibrovascular niches. It is initiated by endothelial dysfunction, followed by heme scavenging of CD163 + macrophages and production of CCL18. This chemokine synergizes with local CCL2...

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Identifiers and source

Literature Corpus work: 4fd94033-8ddf-5956-b010-f051dbbe1603
DOI: 10.1101/2022.03.24.22272768

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