Article
Three Unique Interstitial Macrophages in the Murine Lung at Steady State.
American journal of respiratory cell and molecular biology - 1 Jul 2017
Gibbings Sophie L, Thomas Stacey M, Atif Shaikh M, McCubbrey Alexandra L, Desch A Nicole, Danhorn Thomas, Leach Sonia M, Bratton Donna L, Henson Peter M, Janssen William J, Jakubzick Claudia V
Abstract excerpt
The current paradigm in macrophage biology is that some tissues mainly contain macrophages from embryonic origin, such as microglia in the brain, whereas other tissues contain postnatal-derived macrophages, such as the gut. However, in the lung and in other organs, such as the skin, there are both embryonic and postnatal-derived macrophages. In this study, we demonstrate in the steady-state lung that the...
Topics
- Animals
- Bone Marrow Cells
- Dendritic Cells
- Gene Expression Profiling
- Lung
- Macrophages
- Macrophages, Alveolar
- Mice, Inbred C57BL
- Organ Specificity
- Phagocytes
- Phenotype
- Transcription, Genetic