Article
Automated Manufacturing of Potent CD20-Directed Chimeric Antigen Receptor T Cells for Clinical Use.
Human gene therapy - 1 Oct 2017
Lock Dominik, Mockel-Tenbrinck Nadine, Drechsel Katharina, Barth Carola, Mauer Daniela, Schaser Thomas, Kolbe Carolin, Al Rawashdeh Wael, Brauner Janina, Hardt Olaf, Pflug Natali, Holtick Udo, Borchmann Peter, Assenmacher Mario, Kaiser Andrew
Abstract excerpt
The clinical success of gene-engineered T cells expressing a chimeric antigen receptor (CAR), as manifested in several clinical trials for the treatment of B cell malignancies, warrants the development of a simple and robust manufacturing procedure capable of reducing to a minimum the challenges associated with its complexity. Conventional protocols comprise many open handling steps, are labor intensive, and are...
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