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Article

Pdr1 regulates multidrug resistance in <i>Candida glabrata</i>: gene disruption and genome‐wide expression studies

27 Jun 2006

Abstract excerpt

Candida glabrata emerged in the last decade as a common cause of mucosal and invasive fungal infection, in large part due to its intrinsic or acquired resistance to azole antifungals such as fluconazole. In C. glabrata clinical isolates, the predominant mechanism behind azole resistance is upregulated expression of multidrug transporter genes CDR1 and PDH1. We previously reported that azole-resistant mutants (MIC...

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PMID: 16803598
DOI: 10.1111/j.1365-2958.2006.05235.x

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