Article

Mrr1 regulation of methylglyoxal catabolism and methylglyoxal-induced fluconazole resistance in <i>Candida lusitaniae</i>

2020-05-18

Abstract excerpt

In Candida species, the transcription factor Mrr1 regulates azole resistance genes in addition to the expression of a suite of other genes including known and putative methylglyoxal reductases. Methylglyoxal (MG) is a toxic metabolic byproduct that is significantly elevated in certain disease states that frequently accompany candidiasis, including diabetes, kidney failure, sepsis, and inflammation. Through the ge...

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Literature Corpus work: 48b1f32d-6d40-5f58-8729-52636419feb2
DOI: 10.1101/2020.05.18.101840

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