Article

Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in <i>Pseudomonas aeruginosa</i>

2024-01-16

Abstract excerpt

<h4>ABSTRACT</h4> The opportunistic pathogen Pseudomonas aeruginosa infects cystic fibrosis (CF) patient airways and produces a virulence factor Cif that is associated with worse outcomes. Cif is an epoxide hydrolase that reduces cell-surface abundance of the cystic fibrosis transmembrane conductance regulator (CFTR) and sabotages pro-resolving signals. Its expression is regulated by a divergently transcribed Te...

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Literature Corpus work: 4f88ec08-fa86-50ca-98a3-ed8db870aaec
DOI: 10.1101/2024.01.16.572601

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