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Article

Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa.

Journal of bacteriology - 1 Oct 2012

Ballok Alicia E, Bahl Christopher D, Dolben Emily L, Lindsay Allia K, St Laurent Jessica D, Hogan Deborah A, Madden Dean R, O'Toole George A

Abstract excerpt

Pseudomonas aeruginosa secretes an epoxide hydrolase virulence factor that reduces the apical membrane expression of ABC transporters such as the cystic fibrosis transmembrane conductance regulator (CFTR). This virulence factor, named CFTR inhibitory factor (Cif), is regulated by a TetR-family, epoxide-responsive repressor known as CifR via direct binding and repression. We identified two sites of CifR binding in...

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Identifiers

PMID: 22843844
DOI: 10.1128/JB.00984-12
PMCID: PMC3457200

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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