Article
Biology and Regulatory Roles of Nuclear Lamins in Cellular Function and Dysfunction.
Recent patents on endocrine, metabolic & immune drug discovery - 1 Jan 2015
Khadija Syeda G, Chen Fei, Hadden Timothy, Commissaris Randall L, Kowluru Anjaneyulu
Abstract excerpt
Nuclear lamins, namely lamins A, B and C, surround the nucleoplasmic contents in a meshlike network called the nuclear lamina. These intermediate filaments provide a structural framework to the nuclear envelope (NE), play a role in arrangement of the chromatin within the nucleus, in DNA replication and also participate in DNA damage repair. In order for lamins to be involved in these important nuclear processes...
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