Article

Functional primary human 3D skeletal muscle organoids enable exercise and metabolic research

2026-06-30

Abstract excerpt

Human skeletal muscle is the principal site of insulin-stimulated glucose disposal and a major mediator of exercise-induced metabolic benefits, yet human models that preserve metabolic and exercise responsiveness remain limited. We generated primary human skeletal muscle organoids from donor-derived CD56+ myoblasts using a collagen-based extracellular matrix and serum-free IGF1-guided differentiation. The organoid...

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Literature Corpus work: 4f824b8b-3991-5109-becc-f505fbc35f32
DOI: 10.64898/2026.06.29.735246

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