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Electrical stimulation of biofidelic engineered muscle enhances myotube size, force, fatigue resistance, and induces a fast-to-slow-phenotype shift.

Physiological reports - 1 Oct 2024

Pallotta Isabella, Stec Michael J, Schriver Brian, Golann David R, Considine Kevin, Su Qi, Barahona Victor, Napolitano Julia E, Stanley Sarah, Garcia Meghan, Feric Nicole T, Durney Krista M, Aschar-Sobbi Roozbeh, Bays Nathan, Shavlakadze Tea, Graziano Michael P

Abstract excerpt

Therapeutic development for skeletal muscle diseases is challenged by a lack of ex vivo models that recapitulate human muscle physiology. Here, we engineered 3D human skeletal muscle tissue in the Biowire II platform that could be maintained and electrically stimulated long-term. Increasing differentiation time enhanced myotube formation, modulated myogenic gene expression, and increased twitch and tetanic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39384537
DOI: 10.14814/phy2.70051
PMCID: PMC11464147

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