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Article

IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype.

American journal of physiology. Cell physiology - 1 May 2024

Dreher Simon I, Grubba Paul, von Toerne Christine, Moruzzi Alessia, Maurer Jennifer, Goj Thomas, Birkenfeld Andreas L, Peter Andreas, Loskill Peter, Hauck Stefanie M, Weigert Cora

Abstract excerpt

Skeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38690930
DOI: 10.1152/ajpcell.00654.2023
PMCID: PMC11371365

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