Article

Engineering of human myotubes toward a mature metabolic and contractile phenotype

2023-06-12

Abstract excerpt

1. Skeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome...

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Literature Corpus work: 3189dc60-b9cd-512f-a808-9d2d7cc40ec1
DOI: 10.1101/2023.06.12.544344

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