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Article

3D skeletal muscle model recapitulating the myostatin knockout phenotypic and mitochondrial metabolic features.

Physiological reports - 1 Jun 2026

Vernus Barbara, Jublanc Elodie, Chabi Béatrice, Pessemesse Laurence, Cheng-Boivin Zacharie, Gentil Benoit J, Bonnieu Anne, Koechlin-Ramonatxo Christelle, Goustard Bénédicte

Abstract excerpt

3D cell culture, using a variety of bioengineering techniques, enables muscle cells to be cultured in more structural and functional biomimetic conditions than 2D cell culture. Here, we tested the ability of an engineered 3D skeletal muscle model to recapitulate in vivo metabolic muscle response. First, C2C12 myoblasts in 3D cultures showed improved myogenesis, attested by increased differentiation time, myotube...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42304819
DOI: 10.14814/phy2.70947
PMCID: PMC13273021

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