Article

Pathogenic DRP1 variants reveal a role for biomolecular condensation in mitochondrial fission

2026-07-08

Abstract excerpt

Fission is essential for proper mitochondrial function and for cellular homeostasis. Dysfunction in mitochondrial fission is associated with several neurological disorders, including the rare and lethal encephalopathy EMPF1, which is caused by de novo heterozygous DNM1L variants. DNM1L encodes the mitochondrial fission mechanoenzyme DRP1, which can intrinsically self-assemble and induce membrane scission. Wild-...

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Literature Corpus work: 4f7229bc-86b4-5439-92d6-9d0ab0b9dc41
DOI: 10.64898/2026.07.06.735726

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