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Article

NovelDNM1Lvariants impair mitochondrial dynamics through divergent mechanisms

1 Aug 2022

Abstract excerpt

Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin-related protein 1 (DRP1) oligomerisation and membrane constriction, although the precise biophysical mechanisms by which distinct DRP1 variants affect the assembly and activity of different DRP1 domains remains largely unexplored. We...

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PMID: 35914810
DOI: 10.26508/lsa.202101284

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