Article

Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein

2025-04-24

Abstract excerpt

Parkinson’s disease (PD) is a complex neurodegenerative disease with a largely unknown etiology. Although the loss of dopaminergic neurons in the substantia nigra pars compacta is the pathological hallmark of PD, neuroinflammation also plays a fundamental role in PD pathology. We have previously reported that PD patients have increased frequencies of T cell reactive to peptides from α -synuclein ( α -syn). Howev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f1da20c-8f69-577c-84af-1ec0c1f06045
DOI: 10.1101/2025.04.21.649867

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synucleinDOI 10.1101/2025.04.21.649867Read

Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signaturesSemantic proximity Read

Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signaturesSemantic proximity Read

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s diseaseSemantic proximity Read

Immune Profiling of Parkinson’s Disease Revealed Its Association With a Subset of Infiltrating Cells and Signature GenesSemantic proximity Read

Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencingSemantic proximity Read

T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s diseaseSemantic proximity Read

Lymphocyte-Activation Gene 3 (LAG3) Protein as a Possible Therapeutic Target for Parkinson’s Disease: Molecular Mechanisms Connecting Neuroinflammation to α-Synuclein Spreading PathologySemantic proximity Read

PINK1 is a target of T cell responses in Parkinson’s diseaseSemantic proximity Read

The spatial landscape of glial pathology and T-cell response in Parkinson’s disease substantia nigraSemantic proximity Read

Adaptive Immunity and Parkinson's Disease.Semantic proximity Read

CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease.Semantic proximity Read

CSF single-cell RNA sequencing reveals clonally expanded CD4 <sup>+</sup> stem cell-like memory T cells in GAD65-antibody associated neurological syndromesSemantic proximity Read