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T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s disease

2025-04-24

Abstract excerpt

A role of the immune system in Parkinson’s disease (PD) progression has long been suspected due to the increased frequency of activated glial cells and infiltrating T cells into the substantia nigra. It was previously reported that PD donors have increased T cell responses towards PINK1 and α-synuclein (α-syn), two Lewy body-associated proteins. Further, T cell reactivity towards α-syn was highest closer to diseas...

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Literature Corpus work
c4f7c851-89df-5bbb-8ec1-f63e480da02f
DOI
10.1101/2025.04.21.649871
Open publication

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T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s diseaseDOI 10.1101/2025.04.21.649871
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