Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures

Abstract excerpt

Parkinson's disease (PD) is a multi-stage neurodegenerative disorder with largely unknown etiology. Recent findings have identified PD-associated autoimmune features including roles for T cells. To further characterize the role of T cells in PD, we performed RNA sequencing on PBMC and peripheral CD4 and CD8 memory T cell subsets derived from PD patients and age-matched healthy controls. When the groups were...

Topics

Join the communities discussing this publication.

• Neuroinflammation and Neurodegeneration Mechanisms
• Nuclear Receptors and Signaling
• Parkinson's Disease Mechanisms and Treatments