Article

From birth to disease: 3D telomere archtecture and aurora kinase changes in Down syndrome

2025-08-22

Abstract excerpt

<title>Abstract</title> <p> Down syndrome (DS) is a chromosomal disorder associated with heightened genomic instability and a significantly increased risk of hematologic malignancies, particularly leukemia. In this study, we employed quantitative 3D telomere imaging and gene expression analysis to investigate nuclear telomeric architecture and aurora kinase ( <italic>AURKA</italic> and <italic>AURKB</italic>...

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Literature Corpus work: 4f04e1b1-4f41-5115-8524-74b7c983ec42
DOI: 10.21203/rs.3.rs-7320263/v1

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