Article
The synergistic effects of the VH families and CH regions of multimeric IgM on its interaction with FcμR, and antigen
2022-05-20
Abstract excerpt
As the primary response antibody with increasing interest as a therapeutic antibody format, IgM is also the largest antibody structure among the five major human isotypes. Spontaneously forming pentamer and hexamers, IgM has avidity effects that could compensate for weaker interactions, although steric hindrances can occur for certain epitopes. With recent evidence of the heavy chain constant region affecting anti...
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Identifiers and source
- Literature Corpus work
- 4ef9f6c9-6cf0-526b-9565-920eaa5049a6
- DOI
- 10.1101/2022.05.19.492610