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Article

A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans.

Nature communications - 22 Aug 2026

Gopal Sharada, Chaturbedi Amaresh, Ramachandrula Tej, OuYang John, Rodell Rebecca, Lee Siu Sylvia

Abstract excerpt

The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation. Loss of NHR-49 causes inappropriate oocyte activation and laying of unfertilized oocytes in the absence of sperm, resulting in rapid...

Read the complete abstract on PubMed

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Longevity
Reproduction
Oocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Receptors, Cytoplasmic and Nuclear

Hepatocyte Nuclear Factor 4

Ovulation

Female

Fertility

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42768050
DOI: 10.1038/s41467-026-77056-4
PMCID: PMC13594228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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