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Article

The advent of AAV9 expands applications for brain and spinal cord gene delivery

20 Apr 2012

Abstract excerpt

INTRODUCTION: Straightforward studies compared adeno-associated virus (AAV) serotypes to determine the most appropriate one for robust expression in the CNS. AAV9 was efficient when directly injected into the brain, but more surprisingly, AAV9 produced global expression in the brain and spinal cord after a peripheral, systemic route of administration to neonatal mice. AREAS COVERED: Topics include AAV9 gene...

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PMID: 22519910
DOI: 10.1517/14712598.2012.681463

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