Article

REACT (Real-world Emulated Clinical Trials): A Framework for Drug Repurposing Applied to Osteoporotic Fractures

2026-03-23

Abstract excerpt

Osteoporotic fractures remain common despite available therapies, highlighting the need for new, safe, and affordable treatment options. Advances in real-world data and causal inference have enabled target trial emulation, with prior frameworks demonstrating drug repurposing using observational data. However, no large-scale trial emulation framework has been applied to systematic drug repurposing for osteoporotic...

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Literature Corpus work: bc921968-adcd-5b7b-852c-d974ea3bcc36
DOI: 10.64898/2026.03.20.26348832

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