The Secretomes of Painful Versus Nonpainful Human Schwannomatosis Tumor Cells Differentially Influence Sensory Neuron Gene Expression and Sensitivity

Abstract excerpt

Schwannomatosis is a multiple tumor syndrome in which patients develop benign tumors along peripheral nerves throughout the body. The first symptom with which schwannomatosis patients often present, prior to discovery of tumors, is pain. This pain can be debilitating and is often inadequately alleviated by pharmacological approaches. Schwannomatosis-associated pain can be localized to the area of a tumor, or wides...

Topics

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• Gastrointestinal Tumor Research and Treatment
• Meningioma and schwannoma management
• Neuroblastoma Research and Treatments
• Neurofibromatosis and Schwannoma Cases
• Pain Mechanisms and Treatments
• Sarcoma Diagnosis and Treatment

Identifiers and source

Literature Corpus work

53501368-aebc-57a1-8c66-9b9d56e9b7c9

DOI

10.1101/734699