Article

Exploring cardiac phenotypes of Drosophila orthologues of human genes associated to Brugada Syndrome (BrS)

2025-07-11

Abstract excerpt

<h4>SUMMARY</h4> Brugada syndrome (BrS) is a rare cardiac arrhythmic disorder with high risk of sudden cardiac death. Recent advances have identified more than 20 risk loci with complex inheritance suggesting a polygenic model for BrS inheritance. These loci are in non-coding regions located in the vicinity of cardiac-expressed genes. This complex genetic architecture and the limited understanding of BrS genetic...

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Literature Corpus work: 4e366483-1958-5c6d-9041-95eb7fbdba3e
DOI: 10.1101/2025.07.08.663711

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