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Article

Single-cell transcriptomics trajectory and molecular convergence of clinically relevant mutations in Brugada syndrome.

American journal of physiology. Heart and circulatory physiology - 1 May 2021

Tambi Richa, Abdel Hameid Reem, Bankapur Asma, Nassir Nasna, Begum Ghausia, Alsheikh-Ali Alawi, Uddin Mohammed, Berdiev Bakhrom K

Abstract excerpt

Brugada syndrome (BrS) is a rare, inherited arrhythmia with high risk of sudden cardiac death. To evaluate the molecular convergence of clinically relevant mutations and to identify developmental cardiac cell types that are associated with BrS etiology, we collected 733 mutations represented by 16 sodium, calcium, potassium channels, and regulatory and structural genes related to BrS. Among the clinically...

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Identifiers

PMID: 33797273
DOI: 10.1152/ajpheart.00061.2021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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